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. 2021 Jul 14;8:683506. doi: 10.3389/fmed.2021.683506

Figure 4.

Figure 4

BRD4 protein expression level in hepatic tissues of HBV liver fibrosis with different degrees. Immunohistochemistry was performed to examine hepatic BRD4 protein expression in HBV liver fibrosis with F1–F4 according to the Metavir score. The expression level of BRD4 was analysis by Image J software. (A) representative images of BRD4 expression in F1–F4 liver fibrosis. Scale bar: 50 μm. (B) cumulative data of BRD4 expression in F1–F4 liver tissues. Data were expressed as mean ± SEM or median M (P25, P75). Differences between groups were evaluated using two independent samples t-test or Mann-Whitney U rank-sum test. (C) Spearman correlation analysis of the correlation between severity of liver fibrosis and BRD4 expression. (D) Spearman correlation analysis was conducted to assess the correlation between BRD4 expression and AST of patients with liver fibrosis. (E) Spearman correlation analysis was conducted to assess the correlation between BRD4 expression and TBIL of patients with liver fibrosis. BRD4, bromodomain-containing protein 4; HBV, hepatitis B virus; AST, aspartate aminotransferase; TBIL, total bilirubin. *P < 0.05; ***P < 0.0001; ****P < 0.00001.