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. 2021 Jul 14;12:667753. doi: 10.3389/fphar.2021.667753

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Copyright © 2021 Sun, Wu, Bian, Yang, Wang, Meng and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mainly physiological progression of uric acid in the body. Serum uric acid is original from uptake of foods containing a high level of purines as well as catabolism of proteins and other compounds in the human body. About 60% uric acid involves in metabolism process and the rest of uric acid is excreted through the gut and urethra. Urethral excretion is the main way. A series of urate transporters including SLC and ABC transporters expressed in urethra, especially the proximal convoluted tubules, maintain urate homeostasis.