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. 2021 Jul 14;12:667753. doi: 10.3389/fphar.2021.667753

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Copyright © 2021 Sun, Wu, Bian, Yang, Wang, Meng and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Urat-lowering drugs in hyperuricaemia-related diseases. Hyperuricaemia has been proven to be associated with multiple diseases including gout, chronic kidney disease, cardiovascular diseases, metabolic syndrome. The discovery of urate transporters provides new ideas for the development of drugs for the research of hyperuricaemia. In addition to urate transport inhibitors, xanthine oxidase inhibitors, SGLT2 inhibitors, as well as novel urat-lowering drugs like EEAK, Favipiravir, PF-06743649 have been summarized.