Table 5.
Mean plasma concentrations of tryptophan metabolites and relative ratios of the metabolites in the low and high inflammatory groups of patients measured at time t1.
| Inflammatory marker | C-reactive protein (CRP) | Tumor necrosis factor-α (TNF-α) | ||
|---|---|---|---|---|
| *Low (+/−¥SD) | **High (+/−¥SD) | †Low (+/−¥SD) | ††High (+/−¥SD) | |
| TRP (μM) | 56 (4) | 54 (3) | 65 (7) | 67 (6) |
| KYN (μM) | 3.9 (0.2) | 5.1 (0.2) | 3.6 (0.2) | 3.2 (0.1) |
| AA (nM) | 221 (7) | 243 (6) | 212 (7) | 225 (5) |
| KA (nM) | 119 (4) | 144 (4) | 106 (2) | 90 (5) |
| QA (nM) | 1000(44) | 890 (12) | 1030 (70) | 1000 (17) |
| KYN/TRP | 0.071 (0.007) | 0.093 (0.006) | 0.055 (0.007) | 0.047 (0.004) |
| AA/TRP | 0.0040 (0.0003) | 0.0045 (0.0003) | 0.0033 (0.0004) | 0.0033 (0.0003) |
| KA/TRP | 0.0021 (0.0002) | 0.0026 (0.0002) | 0.0016 (0.0002) | 0.0013 (0.0001) |
| QA/TRP | 0.018 (0.002) | 0.0164 (0.0009) | 0.016 (0.002) | 0.015 (0.001) |
| AA/KYN | 0.056 (0.003) | 0.048 (0.002) | 0.059 (0.003) | 0.071 (0.003) |
| KA/KYN | 0.030 (0.002) | 0.028 (0.001) | 0.030 (0.002) | 0.028 (0.002) |
| QA/KYN | 0.25 (0.02) | 0.176 (0.007) | 0.29 (0.02) | 0.31 (0.01) |
| KA/AA | 0.54 (0.02) | 0.59 (0.02) | 0.50 (0.02) | 0.40 (0.02) |
| QA/AA | 4.5 (0.2) | 3.7 (0.1) | 4.9 (0.4) | 4.4 (0.1) |
| QA/KA | 8.4 (0.5) | 6.2 (0.2) | 9.7 (0.7) | 11.1 (0.6) |
*
Mean (n = 11 subjects),.
**
Mean (n = 6 subjects).
†
Mean (n = 3 subjects).
††
Mean (n = 4 subjects).
¥
SD of ratio (Y/X) = Y/X × √ [(SD of Y/Y)2 + (SD of X/X)2−(2 × covariance (Y, X)/(Y × X)]. X and Y are the mean value for any two metabolites. Covariance is zero assuming X and Y are independent.