Table 6.
Mean plasma concentrations of KP metabolites and relative ratios of the metabolites in the low and high inflammatory groups of patients measured at time t2.
| Inflammatory marker | C-reactive protein (CRP) | Tumor necrosis factor-α (TNF-α) | ||
|---|---|---|---|---|
| *Low (+/−¥SD) | **High (+/−¥SD) | †Low (+/−¥SD) | ††High (+/−¥SD) | |
| TRP (μM) | 52 (4) | 47 (3) | 57 (4) | 52 (7) |
| KYN (μM) | 4.0 (0.2) | 4.5 (0.2) | 3.8 (0.1) | 4.3 (0.2) |
| AA (nM) | 195 (6) | 206 (4) | 177 (5) | 166 (4) |
| KA (nM) | 94 (4) | 120 (5) | 24 (1) | 24 (1) |
| QA (nM) | 900 (31) | 880 (20) | 850 (46) | 930 (28) |
| KYN/TRP | 0.076 (0.007) | 0.095 (0.008) | 0.066 (0.005) | 0.08 (0.01) |
| AA/TRP | 0.0037 (0.0003) | 0.0044 (0.0003) | 0.0031 (0.0002) | 0.0032 (0.0004) |
| KA/TRP | 0.0018 (0.0002) | 0.0026 (0.0002) | 0.00042 (0.00004) | 0.00046 (0.00006) |
| QA/TRP | 0.017 (0.002) | 0.019 (0.001) | 0.015 (0.001) | 0.018 (0.002) |
| AA/KYN | 0.049 (0.002) | 0.046 (0.003) | 0.047 (0.002) | 0.039 (0.002) |
| KA/KYN | 0.024 (0.001) | 0.027 (0.002) | 0.0064 (0.0004) | 0.0056 (0.0004) |
| QA/KYN | 0.23 (0.01) | 0.20 (0.01) | 0.22 (0.01) | 0.22 (0.01) |
| KA/AA | 0.48 (0.03) | 0.58 (0.03) | 0.137 (0.008) | 0.145 (0.008) |
| QA/AA | 4.6 (0.2) | 4.3 (0.1) | 4.8 (0.3) | 5.6 (0.2) |
| QA/KA | 9.5 (0.5) | 7.3 (0.4) | 35 (3) | 39 (2) |
*
Mean (n = 11),.
**
Mean (n = 6).
†
Mean (n = 3).
††
Mean (n = 4).
¥
SD of ratio (Y/X) = Y/X × √ [(SD of Y/Y)2 + (SD of X/X)2−(2 × covariance (Y, X)/(Y × X)]. X and Y are the mean value for any two metabolites. Covariance is zero assuming X and Y are independent.