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. Author manuscript; available in PMC: 2021 Jul 28.
Published in final edited form as: Bioorg Med Chem Lett. 2016 Mar 12;26(9):2129–2132. doi: 10.1016/j.bmcl.2016.03.040

Table 2.

Aryl amide analogs replacing the 2-naphthyl group

graphic file with name nihms-1723048-t0005.jpg
Entry Ar Aβ40 (%)
Inhibitiona 		Notch1 Processing b
2 graphic file with name nihms-1723048-t0006.jpg 58 No change
7 graphic file with name nihms-1723048-t0007.jpg 67 No change
8 graphic file with name nihms-1723048-t0008.jpg 10 n.t.
9 graphic file with name nihms-1723048-t0009.jpg 85 Inhibition
10 graphic file with name nihms-1723048-t0010.jpg 27 n.t.
11 graphic file with name nihms-1723048-t0011.jpg 14 n.t.
12 graphic file with name nihms-1723048-t0012.jpg 40 No change
13 graphic file with name nihms-1723048-t0013.jpg 0 n.t.
14 graphic file with name nihms-1723048-t0014.jpg 50 Inhibition
15 graphic file with name nihms-1723048-t0015.jpg 33 No change
16 graphic file with name nihms-1723048-t0016.jpg 50 Inhibition
a, b

See Table 1 notes, n.t. = not tested.