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. Author manuscript; available in PMC: 2021 Jul 28.
Published in final edited form as: Bioorg Med Chem Lett. 2016 Mar 12;26(9):2129–2132. doi: 10.1016/j.bmcl.2016.03.040

Table 3.

Naphthyl amide analogs with substituted phenyl rings

graphic file with name nihms-1723048-t0017.jpg
Entry R3 R4 R5 R6 Aβ40 (%)
Inhibitiona 		Notch1
Processing b
17 H H Cl Cl 58 No change
18 OH H Cl Cl 41 No change
19 H H F F 34 No change
20 OH H F F 49 No change
21 H F H F 21 n.t.
22 OH F H F 27 n.t.
23 H H OMe H 47 Inhibition
24 OH H OMe H 33 No change
25 H CN H H 31 n.t.
26 H H CN H 31 n.t.
27 H OMe H OMe 35 No change
28 H OMe H H 19 No change
29 H H graphic file with name nihms-1723048-t0018.jpg H 38 Inhibition
a, b

See Table 1 notes, n.t. = not tested.