Figure 1.

Spaghetti plots of ADAS13, CDRSB, and MMSE relative to time of initiation of symptomatic medication for ADNI participants who initiated symptomatic medication. The blue trend lines estimated by LOESS do not demonstrate a cognitive improvement soon after time 0, even though a benefit relative to no treatment cannot be ruled out. Shaded regions depict 95% confidence intervals, not accounting for repeated measures.

Abbreviations: ADAS13, Alzheimer’s Disease Assessment Scale - 13 item cognitive subscale; CDRSB, Clinical Dementia Rating Sum of Boxes; MMSE, Mini Mental State Exam; LOESS, LOcally Estimated Scatterplot Smoothing.