Figure 2.

Plots of mean change in ADAS13, CDRSB, and MMSE among ADNI MCI participants estimated by including all observations (blue circles) or excluding observations after the initiation of symptomatic medication (red triangles) over the first 36 months of follow-up. Covariates include baseline score, APOEe4 carriage, and age. Shaded regions depict 95% confidence intervals. Numbers below each plot are observation counts at each timepoint.

Abbreviations: ADAS13, Alzheimer’s Disease Assessment Scale - 13 item cognitive subscale; CDRSB, Clinical Dementia Rating Sum of Boxes; MMSE, Mini Mental State Exam; MMRM, Mixed Model of Repeated Measures.