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. 2021 Jul 14;12:646362. doi: 10.3389/fgene.2021.646362

FIGURE 2.

FIGURE 2

Genomic profiles of NSCLC patients in the ICI-treated cohort (Rizvi et al., 2018) (A) and TCGA-NSCLC (B) cohorts. The top 20 genes with the highest mutation frequencies and the corresponding clinical information are shown. The top five genes with the highest mutation frequencies in the ICI-treated cohort (Rizvi et al., 2018) were TP53, KRAS, KEAP1, STK11, and PTPRD. The top five genes with the highest mutation frequencies in the TCGA cohort were TP53, TTN, MUC16, CSMD3, and RYR2. The mutation types are indicated as follows: yellow indicates splice site mutations, blue indicates missense mutations, orange indicates frameshift mutations, green indicates in-frame insertions/deletions, and brown indicates nonsense mutations. The clinical characteristics are shown as patient annotations.