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Cellular Origins of CAFs. CAFs can originate from various cell types such as stellate cells, smooth muscle cells, endothelial cells, adipocytes, MSCs, pericytes, epithelial cells as well as normal fibroblasts. CAF, cancer associated fibroblast; EMT, epithelial-mesenchymal transition; EndMT, endothelial to mesenchymal transition; MSC, mesenchymal stem cell.
