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Therapeutic Strategies to Target TAMs in Tumors. Schematic illustrations of the TAM-targeting approaches including inhibition of monocyte/macrophage recruitment (e.g. CXCR4, CCR2 inhibitors) ①, inhibition/elimination of macrophages in the tumor microenvironment (e.g. bisphosphonates) ② and reprogramming of TAMs into immune supportive macrophages (e.g. TLR7/8 agonist) ③ are demonstrated. TAM, tumor associated macrophage; TLR, toll-like receptor.
