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. 2021 Jul 14;12:684149. doi: 10.3389/fphys.2021.684149

FIGURE 2.

FIGURE 2

(A) Action potential waveform of the SNLV and ICMP models. (B) Fast inward current waveform of the SNLV and ICMP models. (D) Slow inward current waveform of the SNLV and ICMP models. (E) Slow outward current waveform of the SNLV and ICMP models. Waveforms in (A,B,D,E) are derived from cell-level simulations during pacing at 500 ms. Bold blue and red lines represent the waveforms of the best fit models, while light blue and red lines represent the wavefronts using the centroids of the six highest clusters. Jitter has been applied to the waveforms using the centroids of the six highest clusters to facilitate visualization. (C) Fold-difference of the parameters of SNLV (blue) and ICMP (red) compared to the endocardial parameter set of the baseline BOFC model. The parameter τw1− of SNLV and ICMP models is 16.6- and 16.7-fold higher than the baseline BOFC model but the bar chart has been truncated at 8 for better visualization of the remaining parameters. (F) Fold-difference of the parameters of ICMP compared to SNLV models.