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. 2021 Jul 14;15:697299. doi: 10.3389/fnins.2021.697299

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Copyright © 2021 Gao, Chen, Xiang, Zhang, Tan, Fan, Liu, Lv and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Associations among AR, brain-related symptoms, and brain regions. The Sankey diagram showed the associations among AR, brain-related symptoms (including depression, anxiety, memory degradation, attention deficit, insomnia, irritability, cognitive impairment, dementia, restlessness, and embarrassment, which were grouped into four categories for cognition problems, psychological problems, memory problems, and activity problems), and brain regions (PCUN, ACC, and others) abstractly based on the relationship between them from knowledge of AR literatures. The brain map on the right was our result of the ALFF analysis presented by the BrainNet toolbox in SPM. AR, allergic rhinitis; PCUN, precuneus; ACC, anterior cingulate cortex; ALFF, amplitude of low-frequency fluctuation.