Fig. 1. Rational design of a new tool for senescent cells detection. (A) Knockdown of α-fuc but not β-gal prevents the progression of drug-induced senescence; therefore, an α-fuc-responsive probe may be useful in detecting senescent cells lacking β-gal expression. (B) Chemical structure of α-fuc-responsive AIEgen (QM-NHαfuc) and schematic illustration of the mechanisms underlying the real-time imaging of senescent cells in vivo.
