KEY RESOURCES TABLE
| REAGENT or RESOURCE | SOURCE | IDENTIFIER |
|---|---|---|
| Antibodies | ||
| Keratin 8 #ab59400 | Abcam | RRID:AB_942041 |
| Keratin 14 #PRB-155P | BioLegend (former Covance) | RRID:AB_292096 |
| Beta-Catenin #8480 | Cell Signaling | RRID:AB_11127855 |
| Histone H3 phospho (Ser10) #3377 | Cell Signaling | RRID:AB_1549592 |
| CD3-HorizonV451 | eBioscience | RRID:AB_1272193 |
| CD19 APC | eBioscience | RRID:AB_469358 |
| Fc Block CD16/32 | BioLegend | RRID:AB_469358 |
| Alexa Fluor 647 Anti-Rabbit IgG | Molecular Probes | RRID:AB_2762835 |
| Anti-DIG AP | Merck | RRID:AB_2313640 |
| Hoechst H33258 | Sigma | No identifier |
| DAPI | Thermo-Fisher Scientific | No identifier |
| Chemicals, Peptides, and Recombinant Proteins | ||
| ACK Lysis Buffer | Gibco | Cat#A1049201 |
| DIG DNA Labelling Mix | Merck | 11277065910 |
| Blocking Reagent | Merck | Cat#11096176001 |
| Positively Charged Nylon Membrane | Merck | Cat#11209272001 |
| CDP-Star | Merck | Cat#11759051001 |
| Horse Serum | Thermo-Fisher Scientific | Cat# 26050088 |
| Triton X-100 | Sigma-Aldrich | Cat#T878 |
| GoTaq Master-Mix | Promega | Cat#M7123 |
| TaKaRa PCR Amplification Kit | TaKaRa | Cat#R011A |
| TaKaRa TaqI Kit | TaKaRa | Cat#1189A |
| Nuclease-free Water | Thermo-Fisher Scientific | Cat#10977035 |
| DABCO | Roth | Cat#0718.2 |
| Mowiol | Roth | Cat#0713.2 |
| Recombinant DNA | ||
| MADM-1-GT targeting vector | This study | N/A |
| MADM-1-TG targeting vector | This study | N/A |
| MADM-2-GT targeting vector | This study | N/A |
| MADM-2-TG targeting vector | This study | N/A |
| MADM-3-GT targeting vector | This study | N/A |
| MADM-3-TG targeting vector | This study | N/A |
| MADM-4-GT targeting vector | This study | N/A |
| MADM-4-TG targeting vector | This study | N/A |
| MADM-5-GT targeting vector | This study | N/A |
| MADM-5-TG targeting vector | This study | N/A |
| MADM-6-GT targeting vector | This study | N/A |
| MADM-6-TG targeting vector | This study | N/A |
| MADM-8-GT targeting vector | This study | N/A |
| MADM-8-TG targeting vector | This study | N/A |
| MADM-9-GT targeting vector | This study | N/A |
| MADM-9-TG targeting vector | This study | N/A |
| MADM-10-GT targeting vector | This study | N/A |
| MADM-10-TG targeting vector | This study | N/A |
| MADM-13-GT targeting vector | This study | N/A |
| MADM-13-TG targeting vector | This study | N/A |
| MADM-14-GT targeting vector | This study | N/A |
| MADM-14-TG targeting vector | This study | N/A |
| MADM-15-GT targeting vector | This study | N/A |
| MADM-15-TG targeting vector | This study | N/A |
| MADM-16-GT targeting vector | This study | N/A |
| MADM-16-TG targeting vector | This study | N/A |
| MADM-17-GT targeting vector | This study | N/A |
| MADM-17-TG targeting vector | This study | N/A |
| MADM-18-GT targeting vector | This study | N/A |
| MADM-18-TG targeting vector | This study | N/A |
| MADM-19-GT targeting vector | This study | N/A |
| MADM-19-TG targeting vector | This study | N/A |
| Oligonucleotides | ||
| See Table S2 | N/A | |
| Experimental Models: Cell Lines | ||
| Parental ES cell line C2, Stock Number: 011989-MU | A. Nagy | MMRRC_011989-MU |
| Experimental Models: Organisms/Strains/Lines | ||
| Mouse: MADM-1-GT | This study | N/A |
| Mouse: MADM-1-TG | This study | N/A |
| Mouse: MADM-2-GT | This study | N/A |
| Mouse: MADM-2-TG | This study | N/A |
| Mouse: MADM-3-GT | This study | N/A |
| Mouse: MADM-3-TG | This study | N/A |
| Mouse: MADM-4-GT | This study | N/A |
| Mouse: MADM-4-TG | This study | N/A |
| Mouse: MADM-5-GT | This study | N/A |
| Mouse: MADM-5-TG | This study | N/A |
| Mouse: MADM-6-GT | This study | N/A |
| Mouse: MADM-6-TG | This study | N/A |
| Mouse: MADM-7-GT | The Jackson Laboratory | RRID:IMSR_JAX:021457 |
| Mouse: MADM-7-TG | The Jackson Laboratory | RRID:IMSR_JAX:021458 |
| Mouse: MADM-8-GT | This study | N/A |
| Mouse: MADM-8-TG | This study | N/A |
| Mouse: MADM-9-GT | This study | N/A |
| Mouse: MADM-9-TG | This study | N/A |
| Mouse: MADM-10-GT | This study | N/A |
| Mouse: MADM-10-TG | This study | N/A |
| Mouse: MADM-11-GT | The Jackson Laboratory | RRID:IMSR_JAX:013749 |
| Mouse: MADM-11-TG | The Jackson Laboratory | RRID:IMSR_JAX:013751 |
| Mouse: MADM-12-GT | The Jackson Laboratory | RRID:IMSR_JAX:021460 |
| Mouse: MADM-12-TG | The Jackson Laboratory | RRID:IMSR_JAX:021461 |
| Mouse: MADM-13-GT | This study | N/A |
| Mouse: MADM-13-TG | This study | N/A |
| Mouse: MADM-14-GT | This study | N/A |
| Mouse: MADM-14-TG | This study | N/A |
| Mouse: MADM-15-GT | This study | N/A |
| Mouse: MADM-15-TG | This study | N/A |
| Mouse: MADM-16-GT | This study | N/A |
| Mouse: MADM-16-TG | This study | N/A |
| Mouse: MADM-17-GT | This study | N/A |
| Mouse: MADM-17-TG | This study | N/A |
| Mouse: MADM-18-GT | This study | N/A |
| Mouse: MADM-18-TG | This study | N/A |
| Mouse: MADM-19-GT | This study | N/A |
| Mouse: MADM-19-TG | This study | N/A |
| Mouse: Emx1-Cre | The Jackson Laboratory | RRID:IMSR_JAX:005628 |
| Mouse: Hprt-Cre | The Jackson Laboratory | RRID:IMSR_JAX:004302 |
| Mouse: Nestin-Cre | Petersen et al. 2002 | N/A |
| Mouse: Apc-flox | The Jackson Laboratory | RRID:IMSR_JAX:009045 |
| Mouse: iv mutant (Dnah11 mutant) | The Jackson Laboratory | RRID:IMSR_JAX:001045 |
| Software and Algorithms | ||
| ZEN Digital Imaging for Light Microscopy | Zeiss | http://www.zeiss.com/microscopy/en_us/products/microscope-software/zen.html#introduction |
| FACS Diva | BD Biosciences | N/A |
| Graphpad Prism 8.0 | Graphpad | https://www.graphpad.com/scientific-software/prism/ |
| FlowJo | Becton, Dickinson and Company; 2019 | https://www.flowjo.com/adobe.com/products/photoshop |
| Photoshop | Adobe | adobe.com/products/photoshop |
| ImageJ | https://imagej.nih.gov/ij/ | |
| Other | ||
| FACS Aria III | BD Biosciences | N/A |
| LSM 800 Confocal | Zeiss | N/A |
| SlideScanner VS120 | Olympus | N/A |
| Cryostat Cryostar NX70 | Thermo Fisher Scientific | N/A |
| Peqlab FUSION SL Advance | Peqlab | N/A |