Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 14;11:701930. doi: 10.3389/fcimb.2021.701930

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Sathler-Avelar, Vitelli-Avelar, Mattoso-Barbosa, Pascoal-Xavier, Elói-Santos, Costa-Rocha, Teixeira-Carvalho, Dick, VandeBerg, VandeBerg and Martins-Filho

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Set of phenotypic/functional biomarkers useful to depict the cardiac lesion status in T. cruzi-infected cynomolgus macaques. (A) Venn diagram analyses were carried out to identify common and selective phenotypic biomarkers in peripheral blood and spleen samples from T. cruzi-infected cynomolgus macaques (CH = ) and non-infected controls (NI = ), and subsequently among subgroups of T. cruzi-infected macaques, classified according to histopathological features of cardiac biopsies and referred as CCC (–) for absence of chronic chagasic cardiopathy (); CCC (+) for mild chronic chagasic cardiopathy () and CCC (++) for moderate chronic chagasic cardiopathy (). (B) Venn diagram analyses were performed to select, within the intracytoplasmic cytokine profile of peripheral blood leukocytes upon TcI-Ag recall in vitro, the common and unique functional biomarkers for T. cruzi-infected cynomolgus macaques (CH) and non-infected controls (NI) and subsequently among the CCC (–), CCC (+) and CCC (++) groups. The selected sets of biomarkers are shown in the figure. Detailed data and conventional statistical analysis is presented in Supplementary Table 1 .

Inline graphic — Set of phenotypic/functional biomarkers useful to depict the cardiac lesion status in T. cruzi-infected cynomolgus macaques. (A) Venn diagram analyses were carried out to identify common and selective phenotypic biomarkers in peripheral blood and spleen samples from T. cruzi-infected cynomolgus macaques (CH = ) and non-infected controls (NI = ), and subsequently among subgroups of T. cruzi-infected macaques, classified according to histopathological features of cardiac biopsies and referred as CCC (–) for absence of chronic chagasic cardiopathy (); CCC (+) for mild chronic chagasic cardiopathy () and CCC (++) for moderate chronic chagasic cardiopathy (). (B) Venn diagram analyses were performed to select, within the intracytoplasmic cytokine profile of peripheral blood leukocytes upon TcI-Ag recall in vitro, the common and unique functional biomarkers for T. cruzi-infected cynomolgus macaques (CH) and non-infected controls (NI) and subsequently among the CCC (–), CCC (+) and CCC (++) groups. The selected sets of biomarkers are shown in the figure. Detailed data and conventional statistical analysis is presented in Supplementary Table 1 .