Table 2.
Surgical and functional outcomes
| Variable | PDD-guided dual LA | Ho:YAG LA (historical control) | p value |
|---|---|---|---|
| (n = 10) | (n = 16) | ||
| Median OT for initial procedure, min (IQR) | 120.0 (98.5–142.5) | 74.5 (50.8–135.3) | 0.097 |
| Primary lesion cleared with URS, n (%) | 10 (100.0) | 13 (81.3) | 0.262 |
| Cleared with one procedure | 7 (70.0) | 10 (62.5) | 0.508 |
| Cleared with staged procedures | 3 (30.0) | 3 (18.8) | |
| Clavien-Dindo complications, n (%) | 0.77 | ||
| Grade 1 | 9 (90.0) | 12 (75.0) | |
| Grade 2 | 1 (10.0) | 3 (18.8) | |
| Febrile urinary tract infection | 1 (10.0) | 3 (18.8) | |
| Grade 3a | 0 (0.0) | 1 (6.2) | |
| Ureteral stricture | 0 (0.0) | 1 (6.2) | |
| Grade 3b/4a/4b/5 | 0 (0.0) | 0 (0.0) | |
| Salvage radical nephroureterectomy, n (%) | 0.009 | ||
| Not required | 10 (100.0) | 8 (50.0) | |
| Required | 0 (0.0) | 8 (50.0) | |
| Median postoperative eGFR, ml/min (IQR) a | 70.5 (47.3–80.5) | 33.0 (23.3–48.0) | 0.014 |
| Median change in eGFR from baseline, % (IQR) | 5.7 (2.9–18.9) | −11.4 (−23.1 to −1.0) | 0.075 b |
eGFR = estimated glomerular filtration rate; IQR = interquartile range; LA = laser ablation; OT = operation time; PDD = photodynamic diagnosis; URS = ureteroscopic surgery.
a
At 1 yr or last visit after URS.
b
Adjusted for baseline eGFR.