Table 4.
Quantitating the effect of location matching on the diagnostic accuracy of mpMRI for grade group ≥2 and ≥3 cancers at PI-RADS ≥4 threshold.
| Sensitivity | Specificity | PPV | NPV | |
|---|---|---|---|---|
| No location matching a | ||||
| Grade group ≥2 | 77.6 | 68.7 | 72.9 | 73.9 |
| Grade group ≥3 | 86.0 | 59.1 | 49.8 | 89.9 |
| Location matching (exact location) | ||||
| Grade group ≥2 | 63.4 | 68.7 | 68.7 | 63.4 |
| Grade group ≥3 | 70.6 | 59.1 | 44.9 | 81.0 |
| Location matching (same or adjacent sector) | ||||
| Grade group ≥2 | 74.6 | 68.7 | 72.1 | 71.4 |
| Grade group ≥3 | 82.5 | 59.1 | 48.8 | 87.7 |
mpMRI = multiparametric magnetic resonance imaging; NPV = negative predictive value; PI-RADS = Prostate Imaging Reporting and Data System; PPV = positive predictive value.
a
No location matching = cancer present anywhere in the gland is considered a “match” for a positive mpMRI lesion.