Fig. 1.

Examples of SRPK1 intensity in benign prostate tissue and various prostate cancer grade groups: (A) benign prostate tissue showing negative SRPK intensity, (B) Gleason grade group 2 showing weak intensity, (C) Gleason grade group 2 showing moderate intensity, (D) Gleason grade group 3 showing moderate intensity, (E) Gleason grade group 5 showing high intensity, and (F) error bars for mean intensity values of SRPK across various stages of prostate cancer progression. Incidental group: PCa detected incidentally on TURP with low volume and Gleason group 1–2, advanced group: PCa detected on TURP with GG >2 and no prior therapy, and CRPC group: PCa detected on TURP in patients with previous diagnosis of PCa and ADT therapy. ADT = androgen deprivation therapy; CRPC = castrate-resistant prostate cancer; GG = grade group; PCa = prostate cancer; SRPK1 = serine-arginine protein kinase 1; TURP = transurethral resection of the prostate.