Table 3.

Hazard ratio of Gleason score, PTEN and SRPK1 intensity for overall survival and cause-specific mortality in the TURP cohort^a

Variables	Hazard ratio	95% Confidence interval	p value
Overall survival
PTEN Positive (scores 1, 2, 3)
Negative (score 0)	2.47	1.97–3.10	<0.0001
Gleason score (score ≤6)
4 + 3	3.21	2.21–4.66	<0.0001
3 + 4	1.81	1.24–2.64	0.002
8	5.07	3.44–7.47	<0.0001
9–10	5.62	4.39–7.47	<0.0001
SRPK1 (score 0, 1, 2)
Score 3	1.99	1.57–2.54	<0.0001
Prostate cancer–specific survival
PTEN positive (scores 1, 2, 3)
Negative (score 0)	2.01	1.47–2.74	<0.0001
Gleason score (score ≤6)
4 + 3	14.36	4.75–43.40	<0.0001
3 + 4	8.04	2.59–24.96	<0.0001
8	28.67	9.77–84.11	<0.0001
9–10	39.79	14.65–108.09	<0.0001
SRPK1 (scores 0, 1, 2)
Score 3	1.64	1.19–2.26	0.002

SRPK1 = serine-arginine protein kinase 1; TURP = transurethral resection of the prostate.

^aSRPK1 scores: 0, negative; 1, weak; 2, moderate; and 3, high.