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. 2021 Jul 14;11:653863. doi: 10.3389/fonc.2021.653863

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Copyright © 2021 Feng, Xiang, Yi, Meng, Chu, Huang, Zhao, Chen, Xiong and Feng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Underlying hub genes and associated interactions in neuroblastoma. (A) The protein-protein-interaction (PPI) network was constructed by String website. (B) Mutual correlations among 18 hub genes filtered by cytoHubba module in Cytoscape software. The dots are colored red when Pearson correlation coefficients approach 1 and dots are colored blue when coefficients reach -1. (C, D) KM curves for CCNB1 and CD9 (D). Expressions were cut by median levels. (both log-rank test p < 0.0001, n = 498).