Table 1.
Inhibitory effect of 1 (OA) and its chemical synthesised derivatives 2–8 (at 40 μg/mL) on the enzyme activity of HAase.
| Compound | MW (g/mol) | Functional group | Inhibition (%) | |
|---|---|---|---|---|
| 1 | 456.7 | / | 59.3 ± 2.4 | |
| 2 | 454.7 | / | 15.9 ± 4.3 | |
| 3 | 474.7 | / | 12.7 ± 3.9 | |
| 4 | 472.7 | / | 37.3 ± 1.4 | |
| 5a | 629.8 | R1= |  |
18.7 ± 3.8 |
| 5b | 563.8 | R1= |  |
25.6 ± 3.8 |
| 5c | 580.2 | R1= |  |
37.6 ± 4.7 |
| 6a | 572.8 | R2= |  |
100.9 ± 4.3 |
| 6b | 545.8 | R2= |  |
100.4 ± 2.4 |
| 6c | 563.8 | R2= |  |
86.3 ± 3.3 |
| 6d | 555.8 | R2= |  |
93.5 ± 3.9 |
| 6e | 606.7 | R2= |  |
83.7 ± 3.3 |
| 6f | 606.7 | R2= |  |
100.6 ± 3.6 |
| 6g | 562.2 | R2= |  |
98.1 ± 0.4 |
| 7a | 629.9 | R3= |  |
27.9 ± 4.0 |
| 7b | 630.9 | R3= |  |
21.3 ± 3.9 |
| 7c | 630.9 | R3= |  |
32.5 ± 1.7 |
| 8a | 693.9 | R4= |  |
20.2 ± 2.6 |
| 8b | 708.0 | R4= |  |
31.8 ± 0.6 |
| 8c | 690.0 | R4= |  |
25.2 ± 4.4 |