Table 1.
Characteristics of the study population showing data for patients with and without cerebral infarction (CI) recruited in KRANIOPHARYNGEOM 2007 between 2007 and 2019.
| Patients | Patients | Case 1 | Case 2 | P value | |
|---|---|---|---|---|---|
| without CI | with CI | ||||
| Patient number, n | 216 | 26 | 1 | 1 | |
| Gender, female/male, n (%) | 113 (52)/103 (48) | 11 (42)/15 (58) | female | male | 0.423a |
| Age at diagnosis (year) | 9.2 (1.3 – 17.9) | 10.1 (1.7 – 15.6) | 5.0 | 2.0 | 0.642a |
| Duration of history (months) | 5 (0.1 – 108) | 7 (0.1 – 96) | 36.0 | 0.5 | 0.735a |
| Follow-up time (year) | 4.9 (0.2 – 13.1) | 3.7 (0.1 – 9.9) | 5.8 | 2.0 | 0.080a |
| BMI at dgx [SDS (21)] | 0.4 (-11.8 – 10.0) | 1.5 (-3.0 – 9.1) | 2.9 | -1.3 | 0.058a |
| Height at dgx [SDS (20)] | -1.0 (-4.9 – 3.6) | -1.0 (-4.2 – 1.8) | -1.1 | 1.8 | 0.974a |
| BMI at last visit [SDS (21)] | 3.0 (-2.0 – 20.8) | 4.4 (-1.1 – 13.2) | 4.1 | 0.7 | 0.044a |
| Height at last visit [SDS (20)] | -0.3 (-3.9 – 3.1) | 0.1 (-4.1 – 2.5) | -0.1 | 1.7 | 0.216a |
| Tumor volume (3D cm³) | 15.7 (0.01 – 286.3) | 25.1 (0.01 – 187.6) | 11.5 | 13.4 | 0.094a |
| Hydrocephalus, n (%) | 76 (35.2) | 21 (80.8) | x | <0.001a | |
| Frequency of surgical interventions, n (%) | 2 (1 – 12) | 2 (1 – 7) | 4 | 1 | 0.528a |
| Degree of first surgical resection, n (%) | 0.091b | ||||
| Complete resection | 49 (23) | 10 (39) | |||
| Incomplete resection | 167 (77) | 16 (62) | x | ||
| no resection | 0 | 0 | x | ||
| Surgical approach at first resection, n (%) | 0.578b | ||||
| Bifrontal | 17 (8) | 2 (8) | |||
| Endoscopy | 4 (2) | 1 (4) | x | ||
| Posterior fossa | 1 (0.5) | 0 | |||
| Transsphenoidal | 38 (18) | 2 (8) | |||
| Transventricular/transcallosal | 8 (4) | 1 (4) | |||
| Unilateral, fronto-temporal or variations of this approach | 145 (67) | 20 (76) | x | ||
| n.a. | 3 (1) | 0 | |||
| Transsphenoidal vs. “other” | 38/175 | 2/24 | 0.269b | ||
| Surgical experience (patient load/year) | 0.611b | ||||
| ≤1 patient per year/centre, n | 174 (80) | 20 (77) | x | x | |
| >1 patient per year/centre, n | 42 (20) | 6 (23) | |||
| Hypothalamic involvement (HI), n (%) | 0.219b | ||||
| No HI | 11 (5) | 0 | |||
| Anterior HI | 60 (28) | 4 (15) | x | ||
| Anterior and posterior HI | 144 (67) | 22 (85) | x | ||
| n.a. | 1 (1) | 0 | |||
| Hypothalamic lesion (HL), n (%) | 0.0007b | ||||
| No HL | 61 (28) | 0 | x | ||
| Anterior HL | 80 (37) | 11 (42) | |||
| Anterior and posterior HL | 74 (34) | 15 (58) | x | ||
| n.a. | 1 (1) | 0 | |||
BMI, body mass index; SDS, standard deviation score; pts., patients; yr., year; HI, presurgical hypothalamic involvement; HL, surgical hypothalamic lesion; n.a., data not available. aall patients with CI, including case #1 and case #2, bpatients with CI, except case #1 and case #2. Depicted are medians and ranges in paraenthesis or frequency and percentage in parenthesis.