Figure 4.

The antitumor potency of ABT-199 combined with HHT was evaluated in OCL-AML3 cell line-derived mouse xenograft models (n = 5 per group). Compared with each agent alone, the combination of ABT-199 with HHT significantly decreased the tumor burden, including tumor size and weight (A–C). Mouse body weight was measured every other day. (D) Bone marrow from mice was embedded in paraffin and stained with H&E. Scale bar, 25 μm. Data represent the mean ± S.D. *P < 0.05 vs the cotreatment groups (E). (*P < 0.05, **P < 0.01, and ***P < 0.001).