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In the MOLM-13 cell lines, compared with each agent alone, ABT-199 combined with HHT downregulated MCL-1, p-ERK expression (A). Strikingly, our results also showed that cotreatment with ABT-199 and HHT inhibited the FLT3/Stat5/MCL-1 signaling cascade, and the protein levels of p-FLT3, p-Stat5, and MCL-1 were determined by Western blotting (B). The total and phosphorylation protein of FLT3 and STAT in a FLT3 ITD-negative cell line were shown by Western blot (C).
