Table 2.

The effect of synergistic inhibition in AML cell lines.

MV4-11
Concentration (nM)		24h		48h
ABT-199	HHT	Fa	CI	Fa	CI
1.25	2	0.352	5.011	0.446	0.253
2.5	4	0.553	0.322	0.528	0.321
5	8	0.582	0.383	0.660	0.620
10	16	0.642	0.120	0.573	0.071
20	32	0.703	0.061	0.694	0.023
MOLM13
Concentration (nM)		24h		48h
ABT-199	HHT	Fa	CI	Fa	CI
1.25	1	0.121	0.2705	0.110	0.4823
2.5	2	0.210	0.1653	0.197	0.2216
5	4	0.256	0.2125	0.312	0.1411
10	8	0.374	0.1711	0.485	0.0845
20	16	0.442	0.2184	0.687	0.0467
OCL-AML2
Concentration (nM)		24h		48h
ABT-199	HHT	Fa	CI	Fa	CI
10	2	0.135	0.097	0.089	0.584
20	4	0.188	0.061	0.121	0.441
40	8	0.207	0.083	0.189	0.205
80	16	0.413	0.011	0.488	0.009
160	32	0.541	0.005	0.566	0.008
320	64	0.641	0.003	0.766	0.001
OCL-AML3
Concentration (nM)		24h		48h
ABT-199	HHT	Fa	CI	Fa	CI
10	2	0.039	0.341	0.054	0.489
20	4	0.033	0.992	0.064	0.753
40	8	0.075	0.312	0.168	0.318
80	16	0.522	0.003	0.648	0.028
160	32	0.688	0.002	0.838	0.014

CI, Combination index.

Fa, Fractional inhibition.