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. 2021 Jul 14;8:685434. doi: 10.3389/fcvm.2021.685434

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Copyright © 2021 Zhang, Wang, Liu, Du and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FER-1 is found to decide DOX-induced mortality. (A) The survival rate of rats from different groups was shown by Kaplan–Meier survival analysis. All rats were injected with DOX (20 mg/kg). Ten rats were recruited in each group. (B) qRT-PCR analysis shows the mRNA expression level of PTGS2 in the indicated organs of rats after injection with saline (Control) and DOX (20 mg/kg) for 4 days with 10 rats in each group. Each experiment was repeated three times. ^∧∧∧P < 0.001 vs. control. *P < 0.05 vs. DOX. DOX, doxorubicin; FER-1, a ferroptosis inhibitor; NEC, a necrosis inhibitor; 3-MA, an autophagy inhibitor; Emricasan, a pan-caspase inhibitor.