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. 2021 Jul 14;8:685434. doi: 10.3389/fcvm.2021.685434

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Copyright © 2021 Zhang, Wang, Liu, Du and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protective effects of FER-1 and DXZ on DOX-induced cardiomyopathy. (A) Representative images of HE staining of heart sections in rats from different groups. Magnification: ×1.2. Scale bar = 1 mm with 10 rats in each group. (B–D) qRT-PCR and Western blot analysis show the mRNA and protein level of PTGS2, in heart tissues of rats with 10 rats in each group. Three mechanical duplications were performed in each sample. (E) qRT-PCR analysis show the mRNA expression of ANP, BNP and MYH7 in heart tissues of rats. (F,G) Echocardiographic analyses of cardiac function in control rats and rats treated by DOX with or without FER-1 or DXZ. Ten rats were included in each group. ***P < 0.001 vs. control. ^∧∧∧P < 0.001 vs. DOX. HE, hematoxylin-eosin; DXZ, dexazoxane; PTGS2, prostaglandin-endoperoxide synthase 2; ANP, natriuretic peptide A; BNP, natriuretic peptide B; MYH7, myosin heavy chain 7; qRT-PCR, quantitative real-time PCR; LVEF, left ventricular ejection fraction; LVFS, left ventricular fractional shortening.