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. 2021 Jul 14;8:685434. doi: 10.3389/fcvm.2021.685434

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Copyright © 2021 Zhang, Wang, Liu, Du and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of HMGB1 and DXZ on DOX-induced ferroptosis of H9c2 rat cardiomyocytes. (A) The Fe²⁺ content of H9c2 cells after drug treatment was detected by assay kits. (B–E) The relative protein expression levels of HMGB1, PTGS2, GPX4, and FTH1 were determined by Western blot. GAPDH served as a reference gene. ***P < 0.001 vs. control. ^∧P < 0.05, ^∧∧P < 0.01, ^∧∧∧P < 0.001 vs. DOX. All experiments were repeated three times. GPX4, glutathione peroxidase-4.