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. Author manuscript; available in PMC: 2022 Mar 17.
Published in final edited form as: J Am Chem Soc. 2021 Mar 3;143(10):3682–3686. doi: 10.1021/jacs.0c12415

Scheme 1.

Scheme 1.

Abbreviated Reaction Scheme Depicting the Enzymatic Process for Oxidation of 4 to (E)-9 and (Z)-9 Catalyzed by Tcz9, Which Non-Enzymatically Coalesce to 10 in the Presence of Watera aKey HMBC correlations for assigning the structure of 10 are included.