Table 5.

Maximal continuous parameter and burst statistic shifts along each axis compared with maximal parameter and burst statistic shifts along a curve fitted to the midline of the functional regime in model parameter space (Fig. 5A) and along a curve fitted to the experimental (myomodulin) points (Fig. 6A)^a

Search axis	IPumpMax (nA)	${\overline{g}}_h$ (nS)	BD (s)	Burst period (s)	IBI (s)
	Maximal change in parameter values within functional regime
${\overline{g}}_h$ modulated		6.8	1.01	2.15	1.144
IPumpMax modulated	0.132		2.057	3.557	1.5
Comodulation (midline)	0.092	10	2.767	6.186	3.414
Comodulation (experimental)	0.111	9.6	3.12	6.81	3.7
	Maximal change in BD within functional regime
${\overline{g}}_h$ modulated		0.4	1.422	2.402	0.981
IPumpMax modulated	0.09		2.797	4.701	1.904
Comodulation (midline)	0.091	9.8	2.857	6.203	3.339
Comodulation (experimental)	0.11	8.8	3.2	6.68	3.49
	Maximal change in burst period within functional regime
${\overline{g}}_h$ modulated		2.2	1.127	3.16	2.033
IPumpMax modulated	0.046		2.783	4.83	2.047
Comodulation (midline)	0.091	9.8	2.857	6.203	3.339
Comodulation (experimental)	0.111	9.6	3.12	6.81	3.7

^aLargest shifts in parameter, BD, and burst period are searched independently to ensure good agreement. Bolded values indicate values which were optimized for during each search, and unbolded values represent shifts in parameters and burst characteristics which correspond to the system at those searched values. The line of comodulation allows for a larger possible shift in temporal burst characteristics than modulation of either current alone, anywhere in the tested functional regimes on the two-parameter map regardless of search method.