Figure 9.

Modeled transporter data. Each panel shows the experimental curves (solid lines) and model predictions (dashed lines) both pre-drug and post-drug administration for three different SSRIs and decynium-22. The main difference between the pre-drug and post-drug administration model curves was a 50% decrease in the reuptake of histamine from the extracellular space into the histamine varicosity. In the cases of escitalopram and decynium-22, the uptake into glial cells was also partially blocked, which is consistent with the fact that the post-drug administration experimental curves are higher and flatter in those two cases.