Figure 3.

Effect of CBD on overall voltage-activated currents in nociceptors. A, Currents evoked by depolarization before and after 2 μm CBD. The 200 ms voltage steps were applied at 0.2 Hz from a holding voltage of −80 mV. The first 90 μs of the test pulse currents are blanked to remove capacity artifacts. Series resistance compensation for 80% of series resistance of 7 MΩ (measured from the time constant of the uncompensated capacity transient). B, Effect of 2 μm CBD on peak inward and peak outward currents as a function of test pulse voltage. Same cell as in A. C, Collected results for the inhibition of peak currents evoked by voltage steps from −80 to −10 mV (inward current) and +20 mV (outward current). Values are the mean ± SEM; n = 13 cells from two animals for 2 μm CBD and n = 7 cells from one animal for 5 μm CBD.