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. 2021 Jul 24;14:3523–3536. doi: 10.2147/JIR.S320912

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© 2021 Fan et al.

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Res inhibited the activation of NLRP3 inflammasomes by promoting mitophagy. BMDM treated with 500 ng/mL LPS for 3 h or 30 μM Res for 6 h, or together with 5 mM 3-MA for 6 h and 300 μg/mL MSU for 6 h. The expression of IL-1β (A) and IL-18 (B) in the supernatant by ELISA; detection of protein expressions in the supernatant (Sup) and cell lysate (Lys) by Western blot (C). Statistical analysis of Cleaved Caspase-1 (D) and Cleaved IL-1β (E) in cell superna-tant and NLRP3 (F), ASC (G), Pro-Caspase-1 (H), and Pro-IL-1β (I) in cell lysates. Data are expressed as mean ± standard deviation. N.S. indicates not significant, * indicates P < 0.05, and ** indicates P < 0.01.