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. 2021 Jul 24;14:3523–3536. doi: 10.2147/JIR.S320912

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© 2021 Fan et al.

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Mechanism of Res-inhibited activation of NLRP3 inflammasomes via mitophagy. MSU induces joint inflammation by causing mitochondrial damage, activating NLRP3 inflammasomes, and promoting the secretion of IL-1β and IL-18. Res alleviates GA by promoting mitophagy to clear damaged mitochondria and inhibit the activation of NLRP3 inflammasomes.