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. 2020 Sep 1;117(9):2108–2124. doi: 10.1093/cvr/cvaa256

Figure 2.

Figure 2

Combination of HFD + ANGII results in a phenotype of concentric LV hypertrophy with preserved FS and diastolic dysfunction. (A) FS (systolic function) (n = 7–11 mice per group). (B) LVAWd (n = 7–11 mice per group). (C) Representative M-mode echocardiographic images of LV. (D) GLS as marker of myocardial deformation per treatment group (n = 6–9 mice per group). (E) Quantification of RPLSR as marker of diastolic function (n = 6–10 mice per group). (F) Pmax aorta measured by intracardiac pressure measurements (n = 5–9 mice per group). FS, fractional shortening; LVAWd, left ventricular anterior wall thickness in diastole; RPLSR, reverse peak longitudinal strain rate; GLS, global longitudinal strain; CTRL, control chow; CTRL + ANGII, angiotensin II treated group on control chow; HFD, high-fat diet; HFD + ANGII, angiotensin II treated group on high-fat diet; Data are presented as mean + standard errors of the mean. *Kruskal–Wallis test followed by Mann–Whitney U test P <0.05 is considered significant.