Fig 6. Blood pressure response to restraint stress (LSD).
Acute responses to restraint-induced blood pressure (BP) and tachycardia in male Ren-bNull mice and wildtype littermate controls (WT) fed low salt diet. First, telemetric recordings were obtained from low salt diet-fed mice in their home cages at baseline. Following 10 minutes of recording, mice were immediately inserted into an acrylic restrainer and telemetric data were acquired for 10 minutes. One-minute recording was averaged, and the systolic BP, diastolic BP, mean BP, and heart rate (A, B, C, and D, respectively) was expressed as mean±standard error of the mean. For purposes of clarity and transparency the individual 10 minutes systolic BP and heart rate (E and F, respectively) average of each animal under baseline and restrained conditions was plotted. Data were analyzed by two-way ANOVA with Sidak’s multiple comparisons procedure. Adjusted p<0.05 was considered significant.