Table 1. Summary demographics of the sample population.
| Variable |
Men (N = 148,248) |
N |
Women (N = 158,000) |
N |
Premenopausal women (N = 36,203) |
N |
Postmenopausal women (N = 104,632) |
N |
| Age at recruitment, years [means (SD)] |
57.1 (8.10) | 148,248 | 56.7 (7.94) | 158,000 | 46.4 (4.24) | 36,203 | 60.5 (5.38) | 104,632 |
| Body mass index, kg/m2 [means (SD)] |
27.8 (4.21) | 147,766 | 27.1 (5.16) | 157,516 | 26.4 (5.24) | 36,131 | 27.2 (5.04) | 104,274 |
| Exposures | ||||||||
| Bioavailable testosterone, nM [means (SD)] |
5.21 (1.54) | 135,020 | 0.36 (0.27) | 121,878 | 0.37 (0.25) | 29,987 | 0.36 (0.28) | 78,887 |
| Free testosterone, nM [means (SD)] |
0.21 (0.06) | 135,020 | 0.01 (0.01) | 121,878 | 0.02 (0.01) | 29,987 | 0.01 (0.01) | 78,887 |
| Total testosterone, nM [means (SD)] |
11.96 (3.69) | 146,869 | 1.12 (0.64) | 134,701 | 1.22 (0.60) | 33,379 | 1.08 (0.66) | 86,956 |
| Albumin, g/liter [means (SD)] |
45.53 (2.61) | 136,952 | 45.02 (2.58) | 145,875 | 44.91 (2.59) | 33,043 | 45.05 (2.56) | 96,955 |
| SHBG, nM [means (SD)] |
39.93 (16.74) | 135,891 | 61.39 (29.55) | 144,423 | 68.07 (32.31) | 32,607 | 59.45 (28.03) | 96,096 |
| Outcomes* | ||||||||
| Annual pretax household income [means (SD)] |
£50,570 (£35,328) |
106,074 | £50,817 (£34,822) |
77,798 | £55,580 (£36,362) |
32,800 | £46,863 (£33,021) | 35,420 |
| <£18,000 [N (%)] | 16,417 (15.48) | 16,417 | 11,265 (14.48) | 11,265 | 3680 (11.22) | 3680 | 6060 (17.11) | 6060 |
| £18,000 to £30,999 [N (%)] |
23,164 (21.84) | 23,164 | 16,621 (21.36) | 16,621 | 5887 (17.95) | 5887 | 8618 (24.33) | 8618 |
| £31,000 to £51,999 [N (%)] |
30,904 (29.13) | 30,904 | 23,631 (30.37) | 23,631 | 10,219 (31.16) | 10,219 | 10,541 (29.76) | 10,541 |
| £52,000 to £100,000 [N (%)] |
27,979 (26.38) | 27,979 | 20,886 (26.85) | 20,886 | 10,170 (31.01) | 10,170 | 8240 (23.26) | 8240 |
| >£100,000 [N (%)] | 7610 (7.17) | 7610 | 5395 (6.93) | 5395 | 2844 (8.67) | 2844 | 1961 (5.54) | 1961 |
| Townsend deprivation index (TDI) [means (SD)] |
−1.5 (2.98) | 148,072 | −1.6 (2.87) | 157,810 | −1.5 (2.93) | 36,147 | −1.7 (2.84) | 104,510 |
| Employed [N (%)] | 83,954 (72.11) | 83,954 | 70,064 (79.58) | 70,064 | 30,994 (86.47) | 30,994 | 30,260 (73.55) | 30,260 |
| Unemployed [N (%)] | 2857 (2.45) | 2857 | 1180 (1.34) | 1180 | 430 (1.20) | 430 | 563 (1.37) | 563 |
| Out of labor force [N (%)] |
5453 (4.68) | 5453 | 3515 (3.99) | 3515 | 778 (2.17) | 778 | 2110 (5.13) | 2110 |
| Retired [N (%)] | 22,012 (18.91) | 22,012 | 5,611 (6.37) | 5611 | 325 (0.91) | 325 | 4745 (11.53) | 4745 |
| Looking after home/family [N (%)] |
700 (0.60) | 700 | 6037 (6.86) | 6037 | 2715 (7.57) | 2715 | 2607 (6.34) | 2607 |
| Skilled job [N (%)] | 84,620 (84.22) | 100,480 | 80,048 (81.20) | 98,578 | 25,981 (83.34) | 31,176 | 45,225 (80.31) | 56,311 |
| Degree level education [N (%)] |
49,432 (40.52) | 121,983 | 48,003 (37.02) | 129,672 | 14,763 (42.72) | 34,558 | 28,857 (35.54) | 81,188 |
| Own accommodation lived in [N (%)] |
132,897 (90.81) | 146,352 | 143,885 (92.12) | 156,188 | 32,589 (90.95) | 35,831 | 96,047 (92.86) | 103,430 |
| Self-reported risk-taker [N (%)] |
48,522 (33.76) | 143,716 | 27,315 (17.94) | 152,238 | 7648 (21.94) | 34,856 | 16,611 (16.45) | 100,967 |
| Self-reported poor/fair health [N (%)] |
40,166 (27.19) | 147,697 | 34,070 (21.64) | 157,470 | 6569 (18.19) | 36,105 | 22,566 (21.64) | 104,279 |
| Cohabiting [N (%)] | 115,206 (78.12) |
147,476 | 112,559 (71.59) |
157,220 | 26,395 (73.07) | 36,123 | 73,962 (71.09) | 104,040 |
| Current smoker [N (%)] | 17,268 (11.65) | 148,184 | 13,171 (8.34) | 157,906 | 3468 (9.58) | 36,188 | 8017 (7.67) | 104,563 |
| Lifetime smoking index [Median (IQR)] |
0.0 (0.0 to 0.7) | 147,722 | 0.0 (0.0 to 0.2) | 157,473 | 0.0 (0.0 to 0.0) | 36,135 | 0.0 (0.0 to 0.3) | 104,254 |
*Household income and all employment variables were restricted to those younger than retirement age at the time of recruitment, i.e., under 60 years for women and under 65 years for men.