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. 2021 Jul 28;7(31):eabg7073. doi: 10.1126/sciadv.abg7073

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Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 8 — Overexpression of METTL3 in human cancer leads to augmented m⁶A signals on HMBOX1. Alteration to this particular m⁶A epitranscriptomic program facilitates the degradation of HMBOX1 mRNAs, causes progressive telomere shortening, inactivates p53 signaling, and eventually generates genomic instability in cancer cells, which drives the full malignant progression.