Table 2.

Adipose tissue distribution and skeletal muscle composition in HFpEF patients and controls

	HFpEF (N = 55)		Control (N = 33)		Unadjusted data	Adjusted data a
	Median	IQR	Median	IQR	P	β (SE)	P
RV EAT, mm	4.6	3.5–5.5	3.2	2.5–3.9	<0.001	0.2 (0.1)	0.03
AV groove EAT, mm	19.2	14.9–24.5	14.9	13.6–17.4	0.001	2.8 (1.6)	0.08
Liver FF, %	6.4	4.2–10.3	4.1	0.9–6.4	0.001	0.5 (0.2)	0.04
Abdominal VAT, cm2	201.2	108.2–242.8	76.8	52.6–142.2	<0.001	22.1 (20.0)	0.27
Abdominal SAT, cm2	388.0	267.1–517.1	247	154.3–328.8	0.001	52.6 (30.9)	0.09
Abdominal VAT/SAT ratio	0.48	0.37–0.69	0.36	0.3–0.5	0.03	0.02 (0.15)	0.87
Thigh SAT, cm2	182.3	105.2–258.9	123.5	75.4–163	0.002	0.12 (0.12)	0.34
Thigh IMAT, cm2	27.0	16–42	15.8	15.1–21.6	0.06	0.29 (0.19)	0.12
Thigh IMAT FF, %	22.3	16.2–28.9	14.3	11.8–17.4	0.006	0.33 (0.18)	0.06
Thigh interMF, cm2	11.0	7.2–18.1	5.0	4.1–6.8	<0.001	0.60 (0.20)	0.003
Thigh intraMF, cm2	16.5	10.8–24.8	11.7	10.8–16	0.11	0.17 (0.13)	0.18
Thigh muscle, cm2	124.4	102.4–157.5	122.5	93.6–143.6	0.71	−2.98 (15.32)	0.85
Psoas muscle, cm2	16.4	13.7–20.6	12.3	8.3–19.9	0.06	0.17 (0.10)	0.10
Paraspinal muscle, cm2	34.7	29.8–43.4	21.1	18.1–31.7	<0.001	7.57 (3.01)	0.01

AV, atrioventricular; EAT, epicardial adipose tissue; FF, fat fraction; HFpEF, heart failure with preserved ejection fraction; IMAT, intermuscular adipose tissue; interMF, intermuscular fat; intraMF, intramuscular fat; IQR, interquartile range; IQR, interquartile range; RV, right ventricular; SAT, subcutaneous adipose tissue; SE, standard error; VAT, visceral adipose tissue.

^a Analyses are adjusted for age, sex, and body surface area. Positive β coefficients indicate higher values in HFpEF patients than controls.