Table 2.

Most important clinical features and side effects of available intravenous iron preparations

Iron preparation	Brand name	Maximal single dose (mg)	Plasma half‐life (h)	Side effects	Tested in heart failure
Sodium ferric gluconate	Ferrlicit®	125	1	Hypersensitivity, nausea, hypotension, cramps, hypertension, dizziness, and chest pain	No
Ferric carboxymaltose	Ferinject®/Injectafer®	15 mg/kg (max 1000 mg in one infusion)	16	Hypersensitivity, hypertension, nausea, flushing, hypophosphatemia, and dizziness	Yes 56 , 57 , 58
Iron sucrose	Venofer®	200–300	6	Hypersensitivity, hypotension, iron overload, diarrhoea, nausea, vomiting, headache, dizziness, hypotension, pruritus, and leg/back cramps	Yes 50 , 54 , 55 , 65
Iron dextran	Dexferrum®	20 mg/kg	60	Fatal and serious hypersensitivity–anaphylaxis, diarrhoea, nausea, vomiting, headache, and dizziness	No
Ferumoxytol	FeraHeme®	510	15	Fatal and serious hypersensitivity–anaphylaxis, diarrhoea, nausea, dizziness, hypotension, and constipation	No