Table 4.
Change in polygraphy data before (initial) vs. after (final) 3 months of sacubritil–valsartan in G2 patients without positive airway pressure treatment
| G2 (n = 8) | |||||
|---|---|---|---|---|---|
| n | Initial | Final | Difference | P value | |
| AHI (events/h) | 8 | 30.10 (26.40–47.60) [17.80–67.00] | 22.75 (14.60–36.90) [2.70–49.10] | −12.40 (−23.60 to 0.35) [−30.30 to 8.90] | 0.059 a |
| AHI < 15/h | 7 | 0 (0) | 2 (25.0) | — | 0.500 b |
| dAHI (events/h) | 8 | 28.00 (25.50–49.10) [16.70–66.00] | 26.00 (10.00–40.50) [0.00–58.30] | −2.10 (−15.50 to 9.20) [−66.00 to 11.50] | 0.375 c |
| AHIobstructive (events/h) | 8 | 22.85 (18.75–24.75) [17.30–27.00] | 11.45 (4.25–19.50) [0.90–23.00] | −11.20 (−16.15 to −6.40) [−20.90 to 5.70] | 0.010 a |
| AHIcentral (events/h) | 8 | 6.50 (0.90–25.60) [0.00–33.70] | 3.90 (1.10–25.10) [0.00–36.40] | 0.00 (−4.75 to 2.70) [−17.70 to 18.70] | 0.919 a |
| OAI (events/h) | 8 | 7.15 (5.60–12.60) [0.00–16.20] | 1.50 (1.05–4.10) [0.00–14.80] | −4.75 (−10.05 to −1.00) [−15.40 to 8.20] | 0.107 a |
| CAI (events/h) | 8 | 2.60 (0.75–5.65) [0.00–22.30] | 1.90 (0.00–7.60) [0.00–22.40] | −0.90 (−4.45 to 0.55) [−9.50 to 20.20] | 0.469 b |
| MAI (events/h) | 8 | 0.45 (0.00–3.25) [0.00–8.40] | 0.05 (0.00–0.95) [0.00–7.40] | 0.00 (−0.90 to 0.50) [−8.30 to 2.70] | 1.000 c |
| HI (events/h) | 8 | 19.85 (17.75–22.90) [9.80–38.70] | 17.25 (4.55–21.70) [2.20–32.20] | −9.00 (−14.90 to 3.05) [−18.90 to 12.50] | 0.170 a |
| HIobstructive (events/h) | 8 | 14.35 (9.30–19.05) [4.70–20.00] | 4.35 (1.55–15.90) [0.70–21.90] | −4.50 (−12.70 to 1.65) [−17.40 to 4.60] | 0.102 a |
| HIcentral (events/h) | 8 | 2.65 (0.00–13.40) [0.00–27.30] | 2.85 (0.25–13.80) [0.00–21.40] | 0.00 (−2.35 to 2.05) [−13.70 to 10.10] | 0.831 a |
| ODI (events/h) | 7 | 31.00 (15.30–55.90) [7.00–60.00] | 24.00 (11.00–45.90) [4.90–47.30] | −12.40 (−26.10 to 6.00) [−31.90 to 15.20] | 0.255 a |
| Mean SpO2 (%) | 7 | 91.30 (90.00–93.00) [89.10–93.00] | 91.80 (91.00–92.10) [89.50–94.40] | 0.40 (−1.00 to 1.80) [−1.60–4.40] | 0.439 a |
| Minimum SpO2 (%) | 7 | 83.00 (75.00–87.00) [71.00–89.00] | 83.00 (81.00–88.00) [79.00–91.00] | 2.00 (−3.00 to 8.00) [−4.00 to 12.00] | 0.291 a |
| Time SpO2 < 90% (min) | 7 | 182.00 (35.00–279.00) [12.00–311.00] | 54.00 (15.00–244.00) [0.00–310.00] | −33.00 (−69.00 to 42.00) [−279.00 to 128.0] | 0.403 a |
| Per cent time SpO2 < 90% (%) | 7 | 19.00 (2.00–48.50) [1.00–55.40] | 10.00 (4.00–27.70) [0.00–45.80] | −9.00 (−20.80 to 3.00) [−47.00 to 11.00] | 0.177 a |
AHI, apnoea–hypopnoea index; CAI, central apnoea index; dAHI, dorsal apnoea–hypopnoea index; HI, hypopnoea index, MAI, mixed apnoea index; OAI, obstructive apnoea index; ODI, oxygen desaturation index; SpO2, oxygen saturation on pulse oximetry.
Quantitative variables were described by medians and (IQ25–75) and [min–max].
a
The statistical tests used are presented on P values for Student's paired test.
b
The statistical tests used are presented on P values for McNemar's test with Yates' corrections.
c
The statistical tests used are presented on P values for Wilcoxon paired test.