Table 2.

Association between neutrophil count, lymphocyte count, NLR and outcomes in BIOSTAT‐CHF

	Whole cohort (n = 1622)		LVEF < 40% (n = 523)		LVEF ≥ 40% (n = 662)
	Hazard ratio (95% CI)	P‐value	Hazard ratio (95% CI)	P‐value	Hazard ratio (95% CI)	P‐value
Mortality and/or HF hospitalization
Neutrophil count per SD increase	1.11 (1.04–1.20)	0.001	1.24 (1.12–1.37)	<0.001	1.02 (0.91–1.14)	0.72
Lymphocyte count per SD increase	0.74 (0.65–0.85)	<0.001	0.59 (0.46–0.75)	<0.001	0.81 (0.65–0.99)	0.041
NLR per SD increase	1.18 (1.11–1.26)	<0.001	1.24 (1.12–1.35)	<0.001	1.10 (0.99–1.23)	0.07
NLR Tertile 1	Baseline		Baseline		Baseline
NLR Tertile 2	1.33 (1.06–1.67)	0.014	1.98 (1.30–3.01)	0.001	1.12 (0.87–1.46)	0.42
NLR Tertile 3	1.72 (1.37–2.15)	<0.001	2.75 (1.84–4.09)	<0.001	1.51 (1.05–2.16)	0.026
Mortality
Neutrophil count per SD increase	1.21 (1.14–1.29)	<0.001	1.46 (1.31–1.63)	<0.001	1.03 (0.90–1.17)	0.69
Lymphocyte count per SD increase	0.40 (0.33–0.48)	<0.001	0.36 (0.26–0.49)	<0.001	0.58 (0.44–0.76)	<0.001
NLR per SD increase	1.38 (1.30–1.46)	<0.001	1.38 (1.26–1.51)	<0.001	1.18 (1.06–1.33)	0.004
NLR Tertile 1	Baseline		Baseline		Baseline
NLR Tertile 2	2.14 (1.55–2.95)	<0.001	4.06 (2.16–7.60)	<0.001	1.51 (0.92–2.48)	0.10
NLR Tertile 3	4.14 (3.10–5.55)	<0.001	7.71 (4.32–13.76)	<0.001	2.30 (1.44–3.68)	<0.001

All hazard ratios adjusted for the BIOSTAT‐CHF risk model, which includes age, HF hospitalization in the previous year, peripheral oedema, systolic blood pressure, estimated glomerular filtration rate, urea, N‐terminal pro‐brain natriuretic peptide, haemoglobin, high‐density lipoprotein cholesterol, sodium and beta‐blocker use.

Bold indicates P < 0.05.