Table 2.
Clinical characteristics of ATTRwt‐CM
| Publication | Study location or setting | Number of patients | Age at diagnosis | Number of male patients | Common cardiac findings | Number of patients with CTS |
|---|---|---|---|---|---|---|
| Connors (2011) 15 | 1 centre in the USA | 82 | Median 73.8 years | 79 (96%) |
Abnormal echocardiogram (99%) Abnormal ECG (93%) |
5/80 (6%) |
| González‐López (2017) 19 | 2 centres in Spain and Italy | 108 | Mean 78.6 years | 88 (81%) |
Atrial fibrillation (56%) Pseudo‐infarct pattern (63%) |
36 (33%) |
| Minamisawa (2016) 21 | 1 centre in Japan | 21 | Mean 74 years | 17 (81%) |
Heart failure (66%) Low QRS voltage (19%) |
5 (24%) |
| Sekijima (2018) 17 | 11 departments across 10 institutes in Japan | 51 | Mean 73.6 years | 41 (82%) |
Cardiac failure (76%) Cardiac conduction defects/arrhythmia (59%) |
23 (45%) |
| Tsutsui (2019) 22 | 1 centre in Japan | 18 | Mean 82.3 years | 12 (67%) |
HFpEF (61%) Low voltage (6%) Atrial fibrillation (50%) |
Not specified |
| Yamada (2020) 23 | 1 centre in Japan | 129 | Mean 78.5 years | 110 (85%) |
LVEF < 50% (41%) Low voltage (36%) Bundle branch block (36%) |
57/106 (54%) |
ATTRwt‐CM, wild‐type transthyretin amyloid cardiomyopathy; CTS, carpal tunnel syndrome; ECG, electrocardiogram; HFpEF, heart failure with preserved ejection fraction; LVEF, left ventricular ejection fraction.