Table 1.
Transition probabilities
| Event | Event rate b | Transformed monthly event rate DT as used in the model |
|---|---|---|
| Stroke | ||
| Ischemic | 0.17 EPPY | 0.014 |
| Haemorrhagic | 0.06 EPPY | 0.005 |
| Pump exchange | ||
| VAD thrombus | 0.06 EPPY | 0.005 |
| VAD failure | 0.01 EPPY | 0.001 |
| Driveline infection | 0.24 EPPY | 0.020 |
| GI bleed | 0.57 EPPY | 0.048 |
| RHF | 0.28 EPPY | 0.025 |
| RVAD | 0.02 EPPY | 7% a |
| Other AEs | 0.45 EPPY | 0.038 |
AE, adverse event; DT, destination therapy; EPPY, events per patient year; GI, gastrointestinal; IPD, individual patient data; MM: medical management; RHF: right heart failure; RVAD: right ventricular assist device; VAD: ventricular assist device.
a
Percentage of the RHF population.
b
ENDURANCE Supplemental data, Medtronic data on file.