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Domain structures of KEAP1 and NRF2. KEAP1 has four domains, the N-terminal Broad complex, Tramtrack and Bric-à-Brac (BTB) domain which binds cullin 3 ubiquitin ligase, an IVR, and the Kelch domain which binds NRF2. NRF2 contains seven functional domains, Neh1–7. Neh1 contains the DNA binding and heterodimerization domain for small maf, while Neh2 is the regulatory domain which interacts with Keap1 via its DLG and ETGE motifs.
