Fig. 11.

Silent agonists. (A) Structures: NS6740, 1,4-diazabicyclo[3.2.2]non-4-yl[5-[3-(trifluoromethyl)phenyl]-2-furanyl]methanone hydrochloride (Pismataro et al., 2020); KC-1 (Chojnacka et al., 2013); TriETMA, triethylmethylammonium (Papke et al., 2014a); diEPP (Papke et al., 2014a); DMPP, 1,1-dimethyl-4-phenylpiperazin-1-ium iodide (Quadri et al., 2016); 2-NDEP, 1,1-diethyl-4(naphthalene-2-yl)piperazin-1-ium (Gulsevin et al., 2019); R-47 (PMP-072), (R)-N-(4-methoxyphenyl)-2-((pyridin-3-yloxy)methyl)piperazine-1-carboxamide (Clark et al., 2014); 31b, 3-(furan-2-yl)-5-(quinuclidin-3-ylmethyl)-1,2,4-oxadiazole methiodide (Quadri et al., 2018b); and a-conotoxin MrIC (image provided by Dr. Alican Gulsevin). (B) Model for NS6740 pharmacophore adapted from (Pismataro et al., 2020) (image provided by Dr. Maria Chiara Pismataro).