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. 2021 Jul;73(3):1118–1149. doi: 10.1124/pharmrev.120.000097

Fig. 2.

Fig. 2

Recently identified putative α7-selective agonists (see Table 1). A-582941 (2-methyl-5-[6-phenylpyridazin-3-yl]octa- hydropyrrolo[3,4-c]pyrrole) (Tietje et al., 2008); ABT-107, 5-(6-[(3R)-1-azabicyclo[2,2,2]oct-3-yloxy] pyridazin-3-yl)-1H-indole (Malysz et al., 2010); ABT-126, (4s)-4-(5-phenyl-1, 3, 4-thiadiazol-2-yloxy)-1-azatricyclo[3.3.1.13, 7]decane (Haig et al., 2018); AQW051, (R)-3-(6-p-tolyl-pyridin-3-yloxy)-1-aza-bicyclo (2.2.2)octane (Feuerbach et al., 2015); AZD0328, (20 R)-spiro-[1-azabicyclo[2.2.2]octane-3,20 (30 H)-furo[2,3-b]pyridine] d-tartrate (Sydserff et al., 2009); BMS-933043, (2R)-N-(6-(1H-imidazol-1-yl)-4-pyrimidinyl)-4′H-spiro[4-azabicyclo[2.2.2]octane-2,5′-[1,3]oxazol]-2′-amine (Cook et al., 2016; Pieschl et al., 2017); BMS-910731, N-(6-methyl-1,3-benzoxazol-2-yl)-3′,5′-dihydro-4-azaspiro[bicyclo[2.2.2]octane-2,4'-imidazole]-2'-amine (Hill et al., 2017); BMS-902483, (1S,2R,4S)-N-isoquinolin-3-yl)-4′H-4-azaspiro[bicyclo[2.2.2]octane-2,5′oxazol]-2′-amine (Hill et al., 2016; 28105289) (Cook et al., 2016); Br-IQ17B, N-[(3R)-1- azabicyclo[2,2,2]oct-3-yl]-5-bromoindolizine-2-carboxamide (Tang et al., 2015); CP-810,123, 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (O'Donnell et al., 2010); EVP-6124 (Prickaerts et al., 2012); FRM-17874 (Stoiljkovic et al., 2015); NS6784, 2-(1,4-diazabicyclo[3.2.2] nonan-4-yl)-5-phenyl-1,3,4-oxadiazole (Briggs et al., 2009); SEN12333, WAY-317538 5-morpholin-4-yl-pentanoic acid (4-pyridin-3-yl-phenyl)-amide (Roncarati et al., 2009); SEN15924, WAY-361789, 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (Zanaletti et al., 2012b); SEN78702, WYE-308775, N‐[5-(5-fluoropyridin-3-yl)‐1H‐pyrazol-3-yl]-4-piperidin-1-ylbutyramide (Zanaletti et al., 2012a); TC-7020, [5-methyl-N-[2-(pyridin- 3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]thiophene-2-carbox-amide (Marrero et al., 2010); and 5-(1-((1S,3R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-1H-1,2,3-triazol-4-yl)-1H-indole (TTIn-1) and related compounds (Arunrungvichian et al., 2015).