TABLE 2.
α7 PAMs (see Figure 4 for select structures)
| PAM | Chemical Name | Type | Reference |
|---|---|---|---|
| 5-HI | 5-Hydroxyindole | I | (Zwart et al., 2002) |
| CCMI | N-(4-Chlorophenyl)-α-[[(4-chloro-phenyl)amino]methylene]-3-methyl-5-isoxazoleacet-amide | I | (Ng et al., 2007) |
| NS-1738 | 1-(5-Chloro-2-hydroxy-phenyl)-3-(2-chloro-5-trifluoromethyl-phenyl)-urea | I | (Timmermann et al., 2007) |
| PNU-120596 | 1-(5-Chloro-2,4-dimethoxy-phenyl)-3-(5-methyl-isoxazol-3-yl)-urea | II | (Hurst et al., 2005) |
| TQS | 4-Naphthalene-1-yl-3a,4,5,9b-tetrahydro-3-H-cyclopenta[c]quinoline-8-sulfonic acid amide | II | (Gronlien et al., 2007) |
| A-867744 | 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide | II | (Faghih et al., 2009) |
| SB-206553 | 3,5-Dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']di pyrrole-1(2H)-carboxamide | II | (Dunlop et al., 2009) |
| JNJ-1930942 | 2-[[4-Fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5-thiazolemethanol | II | (Dinklo et al., 2011) |
| Genestein | 5,7-Dihydroxy-3-(4-hydroxyphenyl)chromen-4-one | I | (Gronlien et al., 2007) |
| Ivermectin | 22,23-Dihydroavermectin B1a + 22,23-dihydroavermectin B1b | I | (Collins and Millar, 2010) |
| LL-00066471 | 4-(5-(4-Chlorophenyl)-2-(2-cyclopropylacetyl)-l, 4-dimethyl-lh-pyrrol-3-yl)benzenesulfonamide | N.D. | (Verma et al., 2021) |
| PAM-2 | (E)-3-furan-2-yl-N-p-tolyl-acrylamide | II | (Targowska-Duda et al., 2019) |
| BNC375 | 4-((1R,3R)-3-(((5-Chloro-2-methoxyphenyl)amino)methyl)-2,2-dimethylcyclopropyl)benzenesulfonamide | I | (Harvey et al., 2019) |
| Compound 28 | 4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide | N.D. | (Sinha et al., 2020) |
| RGM079 | 1-(2',5′-Dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1-propanone | II | (Perez de Vega et al., 2019) |
| JWX-A0108 | 6-(2-Chloro-6-methylphenyl)-2-((3-fluoro-4-methylphenyl)amino)thiazolo[4,5-d]pyrimidin-7(6H)-one | I | (Sun et al., 2019) |
| AVL-3288 | N‐(4‐Chlorophenyl)‐α‐[[(4‐chloro‐phenyl)amino]methylene]‐3‐methyl‐5‐isoxazoleacet‐amide | I | (Thomsen and Mikkelsen, 2012b) |
| B-973 | 3-(3,4-Difluorophenyl)-N-(1-(6-(4-(pyridin-2-yl)piperazin-1-yl)pyrazin-2-yl)ethyl)propanamide | II | (Post-Munson et al., 2017) |
| Compound 111 | 2,4,2′,5′-Tetrahydroxychalcone | II | (Balsera et al., 2014) |
| RO5126946 | 5-Chloro-N-[(1S,3R)-2,2-dimethyl-3-(4-sulfamoyl-phenyl)-cyclopropyl]-2-methoxy-benzamide | I | (Sahdeo et al., 2014) |
| Lu AF58801 | (1S,2S)-2-Phenyl-cyclopropanecarboxylic acid [α(R)-(4-ethoxy-phenyl)-2-hydroxy-ethyl]-amide | I | (Eskildsen et al., 2014) |
N.D., not determined.